While Las Vegas is renowned for its grandeur and over-the-top entertainment, the best casinos in San Diego excel in offering a more relaxed and intimate experience. Understanding the Unique Features of Casino Hotels in San DiegoĬasino hotels in San Diego offer a unique blend of excitement, luxury, and local charm, setting them apart from Las Vegas or other gambling hotspots. Other Top Picks for Casino Hotels in San Diego.The Best Casino in San Diego: Seven Mile Casino.Understanding the Unique Features of Casino Hotels in San Diego.